25 October 2010 - Astex Therapeutics, the UK based biotechnology company developing targeted therapies for oncology and virology, announced that AstraZeneca has selected a candidate drug from its collaborative drug discovery programme aimed at identifying novel, small molecule inhibitors of beta-secretase - a key enzyme implicated in the progression of Alzheimer’s disease. The selection of a candidate drug triggers a milestone payment to Astex which, under the terms of agreement, is eligible also to receive further milestones during clinical development and royalties on commercialisation of products derived from the collaboration. Financial details were not disclosed.
In the collaboration, Astex applied its fragment based drug discovery approach, Pyramid™, to identify novel lead compounds inhibiting the target. AstraZeneca is responsible for progressing the selected candidate drug through clinical development and eventually onto the market... Astex Therapeutics' Press Release -
