Sept. 13, 2010 – Anavex Life Sciences Corp., (“ANAVEX” or the “Company”) (OTCBB: AVXL) announced that the Journal of Psychopharmacology has published an original paper showing that ANAVEX 2-73 and its only and active metabolite ANAVEX 19-144 alleviate neurotoxicity and cognition deficits associated with Alzheimer’s disease.The paper, titled “Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 ligand ANAVEX 2-73, a novel aminotetrahydrofuran derivative”, is available online at sagepub.com and cites biochemical, morphological and behavioral evidence from experiments conducted jointly between INSERM at University of Montpellier 2 and Anavex Life Sciences Corp.
Validated and well-recognized, standard non-transgenic animal models were used to show statistically significant neuroprotective effects via both muscarinic cholinergic and sigma-1 receptor agonism effects.
The authors compare the pharmacological profile of ANAVEX 2-73 to that of donepezil (marketed as ARICEPT(R)), the leading-selling drug approved for the treatment of Alzheimer’s disease, noting the greater potential benefits of ANAVEX 2-73. Amyloid-beta peptide has been shown to result in mitochondrial and endoplasmic reticulum stress, intracellular calcium dysregulation leading to oxidative stress and apoptosis (cell death). The authors point to the role of ANAVEX 2-73 in prevention of oxidative stress and apoptosis and other data suggesting modulation of Bcl-2 and reactive oxygen species... Anavex's Press Release -
