July 10, 2008 – Prana Biotechnology Ltd (NASDAQ: PRAN, ASX: PBT) announced the publication of key research findings with its lead Alzheimer's Disease drug, PBT2. The article titled “Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxyquinoline analogs" [full text] is associated with decreased interstitial Abeta” appears in the current edition of the prestigious scientific journal Neuron, and can be viewed online [abstract].The key findings reported are:
- PBT2 profoundly and rapidly improved cognition in transgenic mice.
- PBT2 prevented the formation of soluble Abeta oligomers, the form of Abeta believed to be the most toxic.
- PBT2 substantially reduced the amount of all forms of Abeta in the transgenic mouse brain, over a nine week period.
- PBT2, within hours of oral administration, significantly lowered soluble (interstitial) Abeta in the brain, sampled using in vivo microdialysis.
- Using a well established model for memory formation, PBT2 protected neurons in living brain tissue from the toxic effects of Abeta which impairs the signaling between neurons in Alzheimer’s disease... Prana Biotechnology's Press Release -
